宗成利 博士 教授 博士生导师

  联系方式：海南省海口市人民大道58号永利集团88304官网药学系，570228

  邮箱：chengli.zong@hainanu.edu.cn

  课题组：http://zong.scigoogle.com/

  1.教育及工作背景

  2020.10-至今  永利集团88304官网 教授

  2016.08-2020.10 默沙东制药公司-美国费城 高级科学家  

  2010.09-2016.05乔治亚大学（university of Georgia）-复杂碳水化合物研究中心（Complex Carbohydrate Research Center）（博士）

  2007.09-2010.07中国海洋大学-永利集团88304官网（硕士）

  2003.09-2007.07中国海洋大学-永利集团88304官网（本科）

2.科研情况

细菌疫苗新策略，新型肿瘤疫苗，疫苗佐剂活性增强研究

永利集团88304官网-迈科康生物科技有限公司“先进疫苗研究联合实验室”-负责人

永利集团-糖类小分子药物及多糖疫苗研究创新团队-负责人

3.研究领域

多糖疫苗，免疫学，药物化学，糖化员工物学

4.代表性项目

（1）肿瘤疫苗

新型原位肿瘤疫苗，基于肿瘤表面特殊抗原的亚单位疫苗。

（2）针对超级耐药菌的多糖疫苗研究

作为肺炎球菌多糖领域的行业专家，参与了默沙东下一代肺炎球菌疫苗的开发：例如细菌的发酵，荚膜多糖的分离，纯化，活化，与CRM197偶联等。参与研究的默沙东多价肺炎球菌结合型疫苗研发V114和V116项目已经进入临床实验。

（3）糖胺聚糖的化员工物学研究

建立了一种可以快速合成糖胺聚糖类化合物的保护基以及纯化策略，为此类化合物的构效关系研究奠定了基础。领导并完成了以下项目：建立了一个硫酸肝素四糖化合物库，通过微阵列筛选，发现了一系列硫酸肝素结合蛋白的底物特点；发现了一个在神经导向过程中起重要作用的硫酸肝素八糖结构；发现了一种可以修饰哺乳动物细胞表面的新方法；确定了肿瘤细胞表面一种特殊的硫酸软骨素A。

5.代表性成果

1）Xu, Y. ^#; Yang, J.; Meng, X. ^#; Meng, S.; Sun, T. ^*; Ding, N. ^*; Zong, C. ^*, The synthesis and preliminary immunological evaluation of a dual-adjuvant SARS-CoV-2 RBD vaccine: Covalent integration of TLR7/8 and iNKT cell agonists. International Journal of Biological Macromolecules, 2024, 270, 132258. IF=8.2 一区

2）Meng, X. ^#, Xu, Y. ^#, Yang, J., Meng, S., Ding, N., Sun, T.; Zong, C. ^*, Strategic development of a self-adjuvanting SARS-CoV-2 RBD vaccine: From adjuvant screening to enhanced immunogenicity with a modified TLR7 agonist. International Immunopharmacology, 2024, 132, 111909. IF=5.6 二区

3）Yang, J. ^#; Meng, X.; Rao, Y.; Wang, X.; Meng, S.; Teng, C.; Sun, T. ^*; Zong, C.^*, Harnessing the potential of de-sulfated heparin for targeted drug delivery: A three-component approach exemplified by conjugation with galactose and paclitaxel. Carbohydrate Polymers, 2024, 333, 121986. IF=11.2 一区

4）Weng, W. ^#; Ren, S. ^#; Teng, C. ^#; Guo, J.; Guo, Q.; Zhang, W.; Zong, C.^*; Ding, N.*, Chemoenzymatic Synthesis and Immunological Evaluation of sialyl-Thomsen-Friedenreich (sTF) Antigen Conjugate to CRM197. 2024, Bioorganic & Medicinal Chemistry, 117615. IF=3.5 三区

5）Shen, Y. ^#; Yuan, H. ^#; Guo, Z.; Li, X.; Yang, Z.^*; Zong, C.^*, Exonuclease III Can Efficiently Cleave Linear Single-Stranded DNA: Reshaping Its Experimental Applications in Biosensors. Biosensors, 2023, 13, 581. IF=5.5 二区

6）Teng, C. ^#; Meng, X.; Hu, Y.; Mao, H.; Li, H.; Yang, J.; Sun, T.; Meng, S.; Zong, C.^*, Self-assembled TLR7/8 agonist-mannose conjugate as an effective vaccine adjuvant for SARS-CoV-2 RBD trimer. Polymers, 2022, 14, 5466. IF=5.0 二区

7）Sun, T. ^#; Mai, S-Y. ^#; Mao, H-Z.; Li, H-T.; Duan, Y-Y.; Meng, S.; Bao, J-L.; Ding, N.; Zong, C.^*, Conjugate of Structurally Reassigned Pneumococcal Serotype 31 Polysaccharide with CRM197 Elicited Potent Immune Response. Carbohydrate Polymers, 2022, 289, 119414 IF=11.2 一区

8）Li, H.^#; Chen, C.; Mao, H-Z.; Xu, Y.; Meng, S.; Sun, T-T.; Zong, C.^*, Efficient synthesis of α-galactosylceramide and its C-6 modified analogues, Frontiers in Chemistry, 2022, 10, 1039731 IF=5.5 三区

9）Wan, Y. ^#; Zong, C.^#; Li, X-P.; Wang, A.; Li, Y.; Yang, T.; Bao, Q.; Dubow, M.; Yang, M.^*; Rodrigo, L-A. ^*; Mao, C. ^*, New Insights for Biosensing: Lessons from Microbial Defense System. Chemical Reviews, 2022, 122, 8126-8180 综述 IF=62.1 一区

10）Zong, C.^#; Fang, L.; Song, F.; Wang, A.; Wan, Y.^*, Fluorescent Fingerprint Bacteria by Multi-channel Magnetic Fluorescent Nanosensor. Sensors and Actuators B: Chemical. 2019, 289, 234-241. IF=8.4 一区

11）Zong, C.^#; Venot, A., Li, X.; Lu, W; Xiao, W.; Wilkes, J-W; Salanga, C-L.; Handel, T-M.; Wang, L.; Wolfert, M-A.; Boons, G-J.^*, Heparan Sulfate Microarray Reveals that Heparan Sulfate-Protein Binding Exhibit Different Ligand Requirements. Journal of the American Chemical Society, 2017, 139, 9534-9543. IF=15.0一区

12）Zong, C.^#; Huang, R.; Condac, E.; Chiu, Y.; Xiao, W.; Li, X.; Lu, W.; Ishihara, M.; Wang, S.; Ramiah, A.; Stickney, M.; Azadi, P.; Amster, I-J.; Moremen, K-W.; Wang, L.; Sharp, J-S.; Boons, G-J.^*, Integrated Approach to Identify Heparan Sulfate Ligand Requirements of Robo1. Journal of the American Chemical Society, 2016, 138, 13059-13067. IF=15.0 一区

13）Zong, C.^#; Venot, A.; Dhamale, O-P.; Boons, G-J.^*, Fluorous supported modular synthesis of heparan sulfate oligosaccharides. Org. Lett., 2013, 15, 342–345. IF=5.2一区

14）Zong, C. ^#; Li, Z.; Sun, T.; Wang, P.; Li, Y.^*, “Convenient Synthesis of Sulfated Oligofucosides” Carbohydr. Res. 2010. 11, 1522-1532. IF=3.1 三区

15）Lu, W.^#; Zong, C.; Chopra, P.; Pepi, L.; Xu, Y.; Amster, J.; Liu, J.; Boons, G-J.^*, Controlled chemoenzymatic synthesis of heparan sulfate oligosaccharide. Angewandte Chemie, 2018, 57, 5340-5344. IF=16.6 一区

16）Capicciotti, C. J. ^#; Zong, C.; Sheikh, M.; Sun, T.; Wells, L.; Boons, G-J.^*, Cell-Surface Glyco-Engineering by Exogenous Enzymatic Transfer using a Bi-Functional CMP-Neu5Ac Derivative. Journal of the American Chemical Society, 2017, 139, 13342-13348. IF=15.0 一区

17）Huang, R.^#; Zong, C.; Venot, A.; Chiu, Y.; Zhou, D.; Boons G-J.; Sharp, J.^*, The de novo Sequencing of Complex Mixtures of Heparan Sulfate Oligosaccharides. Analytical Chemistry, 2016, 88, 5299-5307. IF=7.4 一区